Home Pharmaceutical Intermediates Ethyl acetoacetate Ethyl-3-oxo-butanoate

Ethyl acetoacetate Ethyl-3-oxo-butanoate

General
Synonyms: acetoacetic ester, diacetic ether, active acetyl acetate, ethyl 3-oxobutyrate
Molecular formula: C6H10O3
CAS No: 141-97-9
EC No: 205-516-1

Physical data
Appearance: colourless liquid
Melting point: -43 C
Boiling point: 181 C
Vapour density: 4.48
Vapour pressure: 1 mm Hg at 28 C
Specific gravity: 1.021
Flash point: 84 C
Explosion limits: 2% - 15%
Autoignition temperature: 304 C

Stability
Stable. Incompatible with acids, bases, oxidizing agents, reducing agents, alkali metals. Combustible.

Toxicology
Severe eye irritant. Mucous mebrane and respiratory irritant. May be harmful by inhalation, ingestion or through skin absorption.
Toxicity data
ORL-RAT LD50 3980 mg kg-1
ORL-MUS LD50 5105 mg kg-1

Risk phrases
R36 R37 R38 R41.
Personal protection
Safety glasses. Adequate ventilation.
Safety phrases
S26 S36.